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Does a 'western diet' increase risk of Alzheimer's disease?
Does a western diet increase risk of Alzheimer s disease
Does a 'western diet' increase risk of Alzheimer's disease?
Does a western diet increase risk of Alzheimer s disease
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novel inhibitor targets vascular and cognitive defects in ad mice the jackson laboratory : eNews October 28, 2014 Novel inhibitor targets vascular and cognitive defects in AD mice. Mounting evidence indicates that cerebrovascular abnormalities are significantly involved in the development of Alzheimer’s disease (AD).Vascular adhesion protein-1 (VAP-1) is a primary amine oxidase and a drug target for inflammatory and vascular diseases. Despite extensive attempts to develop potent, specific and reversible inhibitors of its enzyme activity, the task has proven challenging. Here we report the synthesis, inhibitory ...Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases. ... et al. Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae ...REVIEW Open Access Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development Guoshuang Shen1†, Fangchao Zheng1,2†, Dengfeng Ren1†, Feng Du3, Qiuxia Dong4, Ziyi Wang1, Fuxing Zhao1, Raees Ahmad1 and Jiuda Zhao1* Abstract Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptorTHE PRESENT AND FUTURE STATE-OF-THE-ART REVIEW Vascular and Metabolic Implications of Novel Targeted Cancer Therapies Focus on Kinase Inhibitors Weijuan Li, MD, MS,* Kevin Croce, MD, PHD,y David P. Steensma, MD,z David F. McDermott, MD,x Ori Ben-Yehuda, MD,k Javid Moslehi, MDRequest PDF on ResearchGate | Novel Pyridazinone Inhibitors for Vascular Adhesion Protein-1 (VAP-1): Old Target-New Inhibition Mode | Vascular adhesion protein-1 (VAP-1) is a primary amine oxidase ...dose. SU11248, a novel small molecule receptor tyrosine kinase inhibitor with direct antitumor as well as antiangiogenic activ-ity via targeting the vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), KIT, and FLT3 receptor tyrosine kinases, was used as the pharmacolog-ical agent in these studies.In the following section we outline a rational approach that we believe has the potential to identify new target sites for novel, dual inhibitors of vascular NOX1 oxidase and NOX2 oxidase ...Tyrosine kinase inhibitors (TKIs) have revolutionized the management and outcomes of chronic myeloid leukemia (CML) patients. Improved disease control and prolonged life expectancy now mandate focus on improving TKIs’ safety profile. Recently, vascular adverse events (VAEs) have emerged as a serious consequence of some of the newer TKIs. In this review, we describe the clinical spectrum of ...
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